RARA / RAR Alpha

retinoic acid receptor, alpha

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

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Products

Proteins (16)

Type

Over-Expression Lysate (8)

Recombinant (8)

Target

RARA / RAR Alpha (16)

Publications

No (16)

Tag

GST (1)

GST, N-terminus (2)

GST, N-terminus + His, C-terminus (1)

His (1)

His-T7 (3)

Myc-DDK (Flag) (8)

Species

Human (10)

Mouse (1)

Rat (1)

Source

293T Cells (4)

E. coli (5)

HEK 293 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (1)

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Human RARA / RAR Alpha Protein (Recombinant His) - LS-G3542

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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RARA / RAR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126631

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

100 µg/$494

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RARA / RAR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126632

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.5 kDa

Price:

100 µg/$494

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RARA / RAR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121083

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

100 µg/$494

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Human RARA / RAR Alpha Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G145024

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

78.6 kDa

Price:

50 µg/$419

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Human RARA / RAR Alpha Protein (Recombinant GST) (Full Length) - LS-G30116

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.56 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RARA / RAR Alpha Protein (Recombinant His-T7) (aa68-173) - LS-G24175

Source:

E. coli

Tag:

His-T7

Molecular Weight:

16.0 kDa

Price:

10 µg/$270; 50 µg/$372; 100 µg/$592; 200 µg/$742; 1 mg/$1,786; 500 µg/$1,352; 5 mg/$2,742; 2 mg/$1,966

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Human RARA / RAR Alpha Protein (Recombinant GST, N-terminus) (aa315-424) - LS-G59864

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RARA / RAR Alpha Protein (Recombinant GST, N-terminus) (aa169-235) - LS-G59866

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RARA / RAR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78213

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

20 µg/$150

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Human RARA / RAR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78214

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

20 µg/$150

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Human RARA / RAR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78216

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.5 kDa

Price:

20 µg/$150

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Human RARA / RAR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78215

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

20 µg/$150

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RARA / RAR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99235

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.6 kDa

Price:

100 µg/$494

Select

Mouse RARA / RAR Alpha Protein (Recombinant His-T7) (aa237-459) - LS-G13161

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.0 kDa

Price:

10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453

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Rat RARA / RAR Alpha Protein (Recombinant His-T7) (aa237-459) - LS-G13166

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.0 kDa

Price:

10 µg/$303; 50 µg/$582; 100 µg/$930; 200 µg/$1,126; 1 mg/$2,327; 500 µg/$1,837; 5 mg/$4,061; 2 mg/$2,519

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