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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RARA / RAR Alpha

retinoic acid receptor, alpha

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

Gene Name: retinoic acid receptor, alpha
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: RARA, NR1B1, PML-RAR, RAR-alpha, RARalpha, Retinoic acid receptor alpha, Pml-rara, RAR, RAR alpha, Retinoic acid receptor, alpha
Target Sequences: NM_000964 NP_000955.1 P10276

Publications (1)

1
Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance. Ren M, Pozzi S, Bistulfi G, Somenzi G, Rossetti S, Sacchi N. Molecular and cellular biology. 2005 25:10591-603. [PubMed:16287870] [PMC:PMC1291229]

Filtered by: None
Type
Over-Expression Lysate (8)
Recombinant (8)
Target
RARA / RAR Alpha (16)
Tag
GST (1)
GST,N-terminus (2)
His (2)
His + T7 (3)
Myc + DDK (8)
Species
Human (10)
Mouse (1)
Rat (1)
Source
293T Cells (4)
E. coli (5)
HEK 293 Cells (4)
Wheat Germ Extract (3)
Purification
Purified (5)
Publications
No (16)
Showing 1-16 of 16 results

RARA / RAR Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G126632
HEK 293 Cells
Myc + DDK
39.5 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

RARA / RAR Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G126631
HEK 293 Cells
Myc + DDK
50.6 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

RARA / RAR Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G121083
HEK 293 Cells
Myc + DDK
50.6 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human RARA / RAR Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G78214
293T Cells
Myc + DDK
50.6 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human RARA / RAR Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G78213
293T Cells
Myc + DDK
50.6 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human RARA / RAR Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G78216
293T Cells
Myc + DDK
39.5 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human RARA / RAR Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G78215
293T Cells
Myc + DDK
50.6 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

RARA / RAR Alpha Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G99235
HEK 293 Cells
Myc + DDK
50.6 kDa
100µg  $365.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human RARA / RAR Alpha Protein (Recombinant His) - LS-G3542
E. coli
His
100µg 1mg/ml  $315.00; 0.5mg 1mg/ml  $695.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human RARA / RAR Alpha Protein (Recombinant His + T7) (aa68-173) - LS-G24175
E. coli
His + T7
16.0 kDa
10µg  $265.00; 50µg  $415.00; 100µg  $530.00; 200µg  $770.00; 1mg  $1,995.00; 500µg  $890.00
Recombinant  Retinoic Acid Receptor Alpha By SDS-PAGE

Human RARA / RAR Alpha Protein (Recombinant GST,N-terminus) (aa315-424) - LS-G59864
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human RARA / RAR Alpha Protein (Recombinant GST,N-terminus) (aa169-235) - LS-G59866
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human RARA / RAR Alpha Protein (Recombinant GST) (Full Length) - LS-G30116
Wheat Germ Extract
GST
76.56 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human RARA stained with Coomassie Blue

Rat RARA / RAR Alpha Protein (Recombinant His + T7) (aa237-459) - LS-G13166
E. coli
His + T7
28.0 kDa
10µg  $325.00; 50µg  $605.00; 100µg  $830.00; 200µg  $1,215.00; 1mg  $3,120.00; 500µg  $1,380.00
Recombinant Retinoic Acid Receptor Alpha By SDS-PAGE

Mouse RARA / RAR Alpha Protein (Recombinant His + T7) (aa237-459) - LS-G13161
E. coli
His + T7
28.0 kDa
10µg  $315.00; 50µg  $575.00; 100µg  $785.00; 200µg  $1,155.00; 1mg  $2,970.00; 500µg  $1,320.00
Recombinant Retinoic Acid Receptor Alpha By SDS-PAGE

Human RARA / RAR Alpha Protein (Recombinant His) - LS-G19995
E. coli
His
14.0 kDa
5µg  $195.00; 25µg  $255.00; 1mg  $2,850.00
Showing 1-16 of 16 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).