RARA / RAR Alpha

retinoic acid receptor, alpha

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

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Products

ELISA Kits (16)

Type

Custom (3)

DNA Binding (1)

DNA Binding Phosphorylation (1)

Sandwich (10)

Sandwich CLIA (1)

Target

RARA / RAR Alpha (16)

Reactivity

Human (7)

Mouse (3)

Rat (2)

Chicken (2)

Dog (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (3)

96-Well Microplate (1)

96-Well Strip Plate (12)

Publications

No (16)

Sample Type

Cell Lysates (2)

Nuclear Lysates (2)

Plasma (5)

Serum (5)

Tissue Homogenates (3)

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Mouse/Human/Rat RARA / RAR Alpha (DNA-Binding ELISA) ELISA Kit - LS-F809

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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Monkey RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F47752

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Chicken RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F47751

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F47754

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F47753

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Sheep RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F47755

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Human RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F13420

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F21261

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Dog RARA / RAR Alpha (Custom ELISA) ELISA Kit - LS-F19707

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Mouse RARA / RAR Alpha (Custom ELISA) ELISA Kit - LS-F19708

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Chicken RARA / RAR Alpha (Custom ELISA) ELISA Kit - LS-F19709

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Human RARA / RAR Alpha (CLIA) ELISA Kit - LS-F30377

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F37121

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F7870

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$818

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Human RARA / RAR Alpha (Sandwich ELISA) ELISA Kit - LS-F4676

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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Mouse/Human Phospho-RARA / RAR Alpha (Ser77) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F906

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

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