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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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RARA / RAR Alpha

retinoic acid receptor, alpha

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

Gene Name: retinoic acid receptor, alpha
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: RARA, NR1B1, PML-RAR, RAR-alpha, RARalpha, Retinoic acid receptor alpha, Pml-rara, RAR, RAR alpha, Retinoic acid receptor, alpha
Target Sequences: NM_000964 NP_000955.1 P10276

Publications (1)

1
Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance. Ren M, Pozzi S, Bistulfi G, Somenzi G, Rossetti S, Sacchi N. Molecular and cellular biology. 2005 25:10591-603. [PubMed:16287870] [PMC:PMC1291229]


RARA / RAR Alpha Antibody - Anti-RARA antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 2C9-1F8] (IgG2a,k) to Human RARA / RAR Alpha
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $495.00
RARA / RAR Alpha Antibody - Anti-RARA antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 2D2] (IgG1,k) to Human RARA / RAR Alpha
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
RARA / RAR Alpha Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-RARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Mouse Monoclonal [clone OTI2C3] (IgG1) to Human RARA / RAR Alpha
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
RARA / RAR Alpha Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-RARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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Mouse Monoclonal [clone OTI2C3] (IgG1) to Human RARA / RAR Alpha
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
RARA / RAR Alpha Antibody - RARA Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Rabbit Polyclonal to Human RARA / RAR Alpha
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
RARA / RAR Alpha Antibody
Select
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $265.00
RARA / RAR Alpha Antibody
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Rabbit Polyclonal to Human RARA / RAR Alpha
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
RARA / RAR Alpha Antibody - Immunohistochemistry of paraffin-embedded rat brain using RARA antibodyat dilution of 1:100 (40x lens).
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200µl   $590.00
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
AP Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200µl   $740.00
RARA / RAR Alpha Antibody - 1:100 staining mouse brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
RARA / RAR Alpha Antibody - 1:200 staining human Testis tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $355.00
Select
Rabbit Polyclonal (IgG) to Rat RARA / RAR Alpha
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $530.00
RARA / RAR Alpha Antibody - Antibody staining (0.03 ug/ml) of Human Brain lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
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Goat Polyclonal to Mouse RARA / RAR Alpha
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
RARA / RAR Alpha Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Retinoic Acid Receptor alpha (Phospho-Ser77) Antibody. The picture on the right is blocked with the phospho peptide.
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Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
RARA / RAR Alpha Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Retinoic Acid Receptor a (Phospho-Ser77) antibody.
Select
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
RARA / RAR Alpha Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Retinoic Acid Receptor a (Phospho-Ser77) antibody.
Select
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).