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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RARA / RAR Alpha

retinoic acid receptor, alpha

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.

Gene Name: retinoic acid receptor, alpha
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: RARA, NR1B1, PML-RAR, RAR-alpha, RARalpha, Retinoic acid receptor alpha, Pml-rara, RAR, RAR alpha, Retinoic acid receptor, alpha
Target Sequences: NM_000964 NP_000955.1 P10276

Publications (1)

1
Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance. Ren M, Pozzi S, Bistulfi G, Somenzi G, Rossetti S, Sacchi N. Molecular and cellular biology. 2005 25:10591-603. [PubMed:16287870] [PMC:PMC1291229]

Filtered by: None
Target
RARA / RAR Alpha (89)
Reactivity
Human (81)
Mouse (39)
Rat (36)
Bat (4)
Bovine (8)
Chicken (4)
Chimpanzee (9)
Dog (8)
Gibbon (9)
Guinea pig (4)
Horse (8)
Monkey (5)
Orangutan (3)
Pig (16)
Rabbit (8)
Application
IHC (26)
IHC-P (7)
WB (88)
Flo (8)
ChIP-Seq (1)
ChrIP (1)
ELISA (19)
ICC (8)
IF (14)
IP (1)
Peptide-ELISA (4)
Host
rabbit (70)
mouse (18)
goat (1)
Isotype
IgG (28)
IgG1 (16)
IgG1,k (1)
IgG2a,k (1)
Clonality
monoclonal mc (18)
polyclonal pc (71)
Clone
2C9-1F8 (1)
2D2 (1)
OTI1C6 (2)
OTI2B4 (2)
OTI2C3 (2)
OTI2D2 (2)
OTI2D5 (2)
OTI2F1 (2)
OTI7B8 (2)
OTI7B9 (2)
Format
AP Conjugated (1)
APC (3)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (8)
Carrier-free (8)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (4)
Unconjugated (50)
Epitope
aa237-459 (16)
aa52-299 (16)
N-Terminus (12)
aa322-349 (8)
aa68-173 (8)
C-Terminus (7)
pSer77 (3)
20-100 aa (2)
aa22-71 (1)
aa46-95 (1)
Publications
No (89)
Showing 1-25 of 89 results

IHC-plus™ RARA / RAR Alpha Antibody (clone 2C9-1F8) LS-B5524
Mouse Monoclonal [clone 2C9-1F8] (IgG2a,k) to Human RARA / RAR Alpha
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg  $495.00
Anti-RARA antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of monoclonal antibody to RARA on A-431 cell. [antibody concentration 10 ug/ml]

RARA / RAR Alpha Antibody (aa52-299, clone OTI2C3) LS-C339986
Mouse Monoclonal [clone OTI2C3] (IgG1) to Human RARA / RAR Alpha
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-RARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
IHC of paraffin-embedded Human prostate tissue using anti-RARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

RARA / RAR Alpha Antibody (aa52-299, clone OTI2C3, Carrier-free) LS-C798321
Mouse Monoclonal [clone OTI2C3] (IgG1) to Human RARA / RAR Alpha
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-RARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-RARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,

IHC-plus™ RARA / RAR Alpha Antibody (clone 2D2) LS-B5525
Mouse Monoclonal [clone 2D2] (IgG1,k) to Human RARA / RAR Alpha
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $495.00
Anti-RARA antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
RARA monoclonal antibody clone 2D2 Western blot of RARA expression in HeLa NE.

RARA / RAR Alpha Antibody (aa322-349) LS-C162444
Rabbit Polyclonal to Human RARA / RAR Alpha
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
RARA Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Confocal immunofluorescence of RARA Antibody with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

RARA / RAR Alpha Antibody (C-Terminus) LS-C137055
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl  $275.00
Western blot Image

RARA / RAR Alpha Antibody LS-C667974
Rabbit Polyclonal to Human RARA / RAR Alpha
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Immunohistochemistry - Paraffin Image
Immunofluorescence Image

RARA / RAR Alpha Antibody LS-C330934
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded rat brain using RARA antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat lung using RARA antibodyat dilution of 1:100 (40x lens).

RARA / RAR Alpha Antibody (aa322-349) LS-C324532
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200µl  $590.00

RARA / RAR Alpha Antibody (aa322-349, Biotin) LS-C284981
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200µl  $740.00

RARA / RAR Alpha Antibody (aa322-349, FITC) LS-C284984
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200µl  $740.00

RARA / RAR Alpha Antibody (aa322-349, AP) LS-C284980
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
AP Conjugated
200µl  $740.00

RARA / RAR Alpha Antibody (aa322-349, APC) LS-C284982
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200µl  $740.00

RARA / RAR Alpha Antibody (aa322-349, Azide-free, HRP) LS-C284983
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

RARA / RAR Alpha Antibody (aa322-349, PE) LS-C284985
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200µl  $740.00

RARA / RAR Alpha Antibody LS-C805967
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

RARA / RAR Alpha Antibody (phospho-Ser77) LS-C800209
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

RARA / RAR Alpha Antibody LS-C755156
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ELISA, IF, IHC, WB
Unconjugated
100µg  $355.00

RARA / RAR Alpha Antibody (C-Terminus) LS-C55366
Goat Polyclonal to Mouse RARA / RAR Alpha
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µg 0.5mg/ml  $405.00
Antibody staining (0.03 ug/ml) of Human Brain lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
Goat Anti-RARA Antibody (1µg/ml) staining of Human Breast (A) and Breast cancer (B) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescencence.

RARA / RAR Alpha Antibody (phospho-Ser77) LS-C199534
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Retinoic Acid Receptor alpha (Phospho-Ser77) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from Jurkat cells treated with PMA 125ng/ml 30' and Jurkat cells treated with insulin 0.01U/ml 15', using Retinoic Acid Receptor alpha (Phospho-Ser77) Antibody. The lane on the right is blocked with the phospho peptide.

RARA / RAR Alpha Antibody (20-100 aa) LS-C381403
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

RARA / RAR Alpha Antibody (20-100 aa) LS-C385785
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

RARA / RAR Alpha Antibody LS-C341705
Rabbit Polyclonal to Human RARA / RAR Alpha
Mouse, Rat, Human
IF, WB
Unconjugated
100µl 1mg/ml  $385.00

RARA / RAR Alpha Antibody LS-C770182
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

RARA / RAR Alpha Antibody (C-Terminus) LS-C347699
Rabbit Polyclonal (IgG) to Human RARA / RAR Alpha
Human
ChrIP, ELISA, WB
Unconjugated
50µl  $405.00
Showing 1-25 of 89 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).