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RAPGEF5 / GFR
Rap guanine nucleotide exchange factor (GEF) 5
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).
| Gene Name: | Rap guanine nucleotide exchange factor (GEF) 5 |
| Synonyms: | RAPGEF5, GFR, KIAA0277, M-Ras-regulated Rap GEF, M-Ras-regulated GEF, MRGEF, Related to Epac, REPAC, MR-GEF |
| Target Sequences: | D87467 BAA13406.2 Q92565 |
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