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20700 44th Avenue W
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RAP1B
RAP1B, member of RAS oncogene family
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
| Gene Name: | RAP1B, member of RAS oncogene family |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , RAS oncogene |
| Synonyms: | RAP1B, GTP-binding protein smg p21B, K-REV, RAS-related protein RAP1B, Ras-related protein Rap-1b, Small GTP binding protein, RAL1B |
| Target Sequences: | NM_015646 NP_056461.1 P61224 |
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