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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RANBP2 / TRP1

RAN binding protein 2

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q.

Gene Name: RAN binding protein 2
Synonyms: RANBP2, 358 kDa nucleoporin, ANE1, E3 SUMO-protein ligase RanBP2, IIAE3, Nucleoporin Nup358, NUP358, Nucleoporin 358, Ran-binding protein 2, TRP1, p270, RAN binding protein 2, TRP2
Target Sequences: NM_006267 NP_006258.3 P49792

Filtered by: None
Target
RANBP2 / TRP1 (8)
Reactivity
Human (8)
Mouse (1)
Bovine (1)
Chimpanzee (1)
Dog (1)
Orangutan (1)
Pig (1)
Application
IHC (4)
IHC-P (3)
WB (4)
ELISA (4)
IP (2)
Host
rabbit (8)
Isotype
IgG (7)
Clonality
polyclonal pc (8)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (5)
Epitope
aa1050-1100 (1)
aa2600-2650 (1)
Publications
No (8)
Showing 1-8 of 8 results

RANBP2 / TRP1 Antibody (aa1050-1100) IHC-plus™ LS-B11329
Rabbit Polyclonal (IgG) to Human RANBP2 / TRP1
Mouse, Human
IHC IHC-P IP WB
Unconjugated
50µl 0.2mg/ml  $425.00
Anti-RANBP2 / TRP1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Detection of Mouse RanBP2 by Western Blot. Samples: Whole cell lysate (50 ug) from NIH3T3, TCMK-1, 4T1, and CT26.WT cells. Antibodies: Affinity purified rabbit anti-RanBP2 antibody used for WB at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

RANBP2 / TRP1 Antibody (aa2600-2650) IHC-plus™ LS-B15058
Rabbit Polyclonal (IgG) to Human RANBP2 / TRP1
Human
IHC IHC-P IP WB
Unconjugated
100µl 0.2mg/ml  $485.00
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

RANBP2 / TRP1 Antibody LS-C396525
Rabbit Polyclonal (IgG) to Human RANBP2 / TRP1
Human
ELISA IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human gastric cancer using antibody at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using antibody at dilution of 1:100.

RANBP2 / TRP1 Antibody (HRP) LS-C396538
Rabbit Polyclonal (IgG) to Human RANBP2 / TRP1
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

RANBP2 / TRP1 Antibody (Biotin) LS-C396540
Rabbit Polyclonal (IgG) to Human RANBP2 / TRP1
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

RANBP2 / TRP1 Antibody (FITC) LS-C396539
Rabbit Polyclonal (IgG) to Human RANBP2 / TRP1
Human
ELISA
FITC Conjugated
50µg  $285.00; 100µg  $385.00

RANBP2 / TRP1 Antibody LS-C355509
Rabbit Polyclonal (IgG) to Human RANBP2 / TRP1
Dog, Bovine, Pig, Orangutan, Human, Chimpanzee
IHC WB
Unconjugated
100µg  $445.00
IHC using RANBP2 Antibody
WB using RANBP2 Antibody

RANBP2 / TRP1 Antibody LS-C662047
Rabbit Polyclonal to Human RANBP2 / TRP1
Human
WB
Unconjugated
100µg  $325.00
Showing 1-8 of 8 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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