RAN

RAN, member RAS oncogene family

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

RAN (8)

Publications

No (8)

Tag

6His, N-terminus (1)

GST (2)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Saccharomyces cerevisiae (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (5)

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Human RAN Protein (Recombinant His) - LS-G816

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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RAN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115381

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.2 kDa

Price:

100 µg/$494

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Human RAN Protein (Recombinant GST) (Full Length) - LS-G30104

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RAN Protein (Recombinant GST) (Full Length) - LS-G30105

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RAN Protein (Recombinant GST, N-terminus) (aa1-216) - LS-G64202

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Saccharomyces cerevisiae RAN Protein (Recombinant 6His, N-terminus) (aa2-219) - LS-G64394

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$679; 20 µg/$429; 1 mg/$1,973

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Human RAN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76316

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.2 kDa

Price:

20 µg/$150

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Human RAN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65799

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.2 kDa

Price:

20 µg/$1,107

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