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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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RAN

RAN, member RAS oncogene family

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Gene Name: RAN, member RAS oncogene family
Family/Subfamily: Ras GTPase superfamily IPR001806 , RAS oncogene
Synonyms: RAN, Gsp1, Guanosine triphosphatase Ran, RanGTPase, Member RAS oncogene family, OK/SW-cl.81, Ras-related nuclear protein, ARA24, TC4, GTPase Ran, Ras-like protein TC4
Target Sequences: NM_006325 NP_006316.1 P62826


RAN Antibody - Anti-RAN antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
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Goat Polyclonal to Human RAN
Xenopus, Chicken, Bovine, Mouse, Dog, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
RAN Antibody - Anti-RAN antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
RAN Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human RAN
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.6mg/ml   $355.00
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Mouse Monoclonal [clone 8D1A6] (IgG1) to Human RAN
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100µl   $365.00
RAN Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
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Rabbit Polyclonal to Human RAN
Drosophila, Mouse, Rat, Hamster, Human, Monkey
WB
Unconjugated
100µl   $530.00
RAN Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with RAN Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human RAN
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
RAN Antibody - RAN antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human RAN
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
RAN Antibody - Immunofluorescence analysis of MCF-7 cells.
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human, Monkey
IF, IHC, IP, RnaIP, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
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Rabbit Polyclonal (IgG) to Human RAN
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $335.00
RAN Antibody - RAN antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Rabbit Polyclonal to Human RAN
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
RAN Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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Rabbit Polyclonal (IgG) to Human RAN
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $285.00; 100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200µl   $590.00
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
AP Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
RAN Antibody
Select
Mouse Monoclonal [clone ARAN1] (IgG2b,k) to Human RAN
Mouse, Rat, Hamster, Human
ICC, IHC, IP, WB
Unconjugated
100µg   1mg/ml   $350.00
RAN Antibody - Western blot of RAN expression in LOVO cells
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Rabbit Polyclonal to Human RAN
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µg   50µl   1mg/ml   $255.00; 100µg   100µl   1mg/ml   $305.00
RAN Antibody - IHC analysis of Ran using anti-Ran antibody. Ran was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-Ran Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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Rabbit Polyclonal to Human RAN
Human
IHC, WB
Unconjugated
100µg   $355.00
RAN Antibody - Western blot analysis of extracts of HL-60 cells, using RAN antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
Flo, IHC, WB
Unconjugated
100µl   $295.00; 200µl   $385.00
RAN Antibody - Western blot of Ran antibody
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
RAN Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using RAN antibody.
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Rabbit Polyclonal (IgG) to Human RAN
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
Viewing 1-25 of 41 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).