Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Reasearch Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

RAN

RAN, member RAS oncogene family

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Gene Name: RAN, member RAS oncogene family
Family/Subfamily: Ras GTPase superfamily IPR001806 , RAS oncogene
Synonyms: RAN, Gsp1, Guanosine triphosphatase Ran, RanGTPase, Member RAS oncogene family, OK/SW-cl.81, Ras-related nuclear protein, ARA24, TC4, GTPase Ran, Ras-like protein TC4
Target Sequences: NM_006325 NP_006316.1 P62826

Filtered by: None
Target
RAN (44)
Reactivity
Human (44)
Mouse (36)
Rat (22)
Bovine (7)
Chicken (5)
Chimpanzee (3)
Dog (7)
Drosophila (5)
Gibbon (3)
Hamster (8)
Horse (5)
Monkey (10)
Orangutan (3)
Pig (6)
Rabbit (4)
Sheep (4)
Xenopus (7)
Zebrafish (4)
Application
IHC (30)
IHC-P (8)
WB (42)
Flo (12)
ELISA (18)
ICC (3)
IF (8)
IP (7)
Peptide-ELISA (3)
RnaIP (1)
Host
rabbit (39)
mouse (3)
goat (2)
Isotype
IgG (28)
IgG1 (2)
IgG2b,k (1)
Clonality
monoclonal mc (3)
polyclonal pc (41)
Clone
8D1A6 (1)
8D1H12 (1)
ARAN1 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (35)
Epitope
aa112-140 (8)
aa143-192 (4)
140-220 aa, C-terminal (1)
Arg28/Asn143 (1)
C-Terminus (1)
Glu202 (1)
aa1-216 (1)
aa12-39 (1)
aa166-216 (1)
aa167-216 (1)
aa175-225 (1)
aa197-210 (1)
aa2-14 (1)
Publications
No (44)
Showing 1-25 of 44 results

IHC-plus™ RAN Antibody (aa2-14) LS-B8294
Goat Polyclonal to Human RAN
Xenopus, Chicken, Bovine, Mouse, Dog, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-RAN antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
Staining (1 ug/ml) of A431 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by chemiluminescence.

RAN Antibody LS-C109538
Rabbit Polyclonal to Human RAN
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 0.6mg/ml  $355.00
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescence of paraformaldehyde-fixed HeLa, using RAN antibody at 1:200 dilution.

RAN Antibody (clone 8D1A6) LS-C669447
Mouse Monoclonal [clone 8D1A6] (IgG1) to Human RAN
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
0.1mg  $365.00

IHC-plus™ RAN Antibody (aa167-216) LS-B7616
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-RAN antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot analysis of lysates from LOVO cells, using RAN Antibody. The lane on the right is blocked with the synthesized peptide.

RAN Antibody LS-C801453
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

RAN Antibody (aa12-39) LS-C162428
Rabbit Polyclonal to Human RAN
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human brain tissue reacted with RAN Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of RAN Antibody in HL-60 cell line lysates (35 ug/lane). RAN (arrow) was detected using the purified antibody.

RAN Antibody (Arg28/Asn143) LS-C93619
Rabbit Polyclonal to Human RAN
Drosophila, Mouse, Rat, Hamster, Human, Monkey
WB
Unconjugated
100µl  $530.00

RAN Antibody (aa143-192) LS-C107810
Rabbit Polyclonal (IgG) to Human RAN
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
RAN antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

RAN Antibody LS-C331176
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human, Monkey
IF, IHC, IP, RnaIP, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of MCF-7 cells.
Immunofluorescence analysis of HeLa cells using RAN antibody. Blue: DAPI for nuclear staining.

RAN Antibody LS-C752508
Rabbit Polyclonal (IgG) to Human RAN
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg  $335.00

RAN Antibody (aa112-140) LS-C162426
Rabbit Polyclonal to Human RAN
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
RAN antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
RAN Antibody western blot of mouse NIH-3T3 cell line lysates (35 ug/lane). The RAN antibody detected the RAN protein (arrow).

RAN Antibody (aa1-216) LS-C376438
Rabbit Polyclonal (IgG) to Human RAN
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human breast cancer using RAN Antibody at dilution of 1:100

RAN Antibody (aa112-140) LS-C324519
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200µl  $590.00

RAN Antibody (aa112-140, Biotin) LS-C239744
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl  $740.00

RAN Antibody (aa112-140, FITC) LS-C239745
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl  $740.00

RAN Antibody (aa112-140, AP) LS-C239742
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
AP Conjugated
200µl  $740.00

RAN Antibody (aa112-140, APC) LS-C239743
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl  $740.00

RAN Antibody (aa112-140, PE) LS-C239749
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
PE Conjugated
200µl  $740.00

RAN Antibody (aa112-140, Azide-free, HRP) LS-C248613
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

RAN Antibody (clone ARAN1) LS-C179422
Mouse Monoclonal [clone ARAN1] (IgG2b,k) to Human RAN
Mouse, Rat, Hamster, Human
ICC, IHC, IP, WB
Unconjugated
100µg 1mg/ml  $350.00
Immunohistochemistry Image
Western blot Image

RAN Antibody LS-C417186
Rabbit Polyclonal to Human RAN
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100µg  $305.00
Western blot of RAN expression in LOVO cells

RAN Antibody LS-C661938
Rabbit Polyclonal to Human RAN
Human
IHC, WB
Unconjugated
100µg  $355.00
IHC analysis of Ran using anti-Ran antibody. Ran was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-Ran Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
IHC analysis of Ran using anti-Ran antibody. Ran was detected in paraffin-embedded section of human lung cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-Ran Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.

RAN Antibody LS-C496703
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Human
Flo, IHC, WB
Unconjugated
100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of HL-60 cells, using RAN antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.

RAN Antibody (140-220 aa, C-terminal) LS-C385773
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Ran antibody

RAN Antibody LS-C402132
Rabbit Polyclonal (IgG) to Human RAN
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.4mg/ml  $205.00; 60µl 0.4mg/ml  $235.00; 120µl 0.4mg/ml  $295.00; 200µl 0.4mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human liver cancer using RAN Polyclonal Antibody at dilution of 1:10.
Western blot analysis of HeLa, NIH/3T3 and HepG2 cell, Mouse testis tissue, using RAN Polyclonal Antibody at dilution of 1:200.
Showing 1-25 of 44 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).