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RALB
v-ral simian leukemia viral oncogene homolog B
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.
| Gene Name: | v-ral simian leukemia viral oncogene homolog B |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806 |
| Synonyms: | RALB, GTP binding protein), RAS-like protein B, Ras-related protein Ral-B |
| Target Sequences: | NM_002881 NP_002872.1 P11234 |
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