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RALA / RAL
v-ral simian leukemia viral oncogene homolog A (ras related)
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
| Gene Name: | v-ral simian leukemia viral oncogene homolog A (ras related) |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806 |
| Synonyms: | RALA, RAL, RAS-like protein A, Ras-related protein Ral-A |
| Target Sequences: | NM_005402 NP_005393.2 P11233 |
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