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Unfortunately, the antibody (ID:158662) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



RAG2 / RAG-2

recombination activating gene 2

Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3.

Gene Name: recombination activating gene 2
Synonyms: RAG2, RAG-2
Target Sequences: M94633 AAH22397.1 P55895

Filtered By: None
Target
rag2-rag-2 (13)
Reactivity
Human (13)
Mouse (5)
Rat (6)
Bovine (4)
Dog (4)
Gibbon (3)
Pig (4)
Application
IHC (2)
IHC-P (3)
WB (13)
Flo (1)
ELISA (3)
ICC (2)
IF (3)
Host
rabbit (11)
mouse (2)
Isotype
IgG (4)
IgG1 (1)
IgG2b,k (1)
Clonality
monoclonal mc (2)
polyclonal pc (11)
Clone
2G8 (1)
4D5 (1)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (10)
Epitope
C-Terminus (4)
aa271-527 (1)
aa348-377 (1)
aa498-527 (1)
Publications
No (13)
Showing 1-13 out of 13 results
Anti-RAG2 / RAG-2 Antibody (aa498-527) LS-C408005

Rabbit Polyclonal to Human RAG2 / RAG-2
Mouse, Rat, Human
IHC-P WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody (clone 4D5) LS-C109145

Mouse Monoclonal [clone 4D5] (IgG1) to Human RAG2 / RAG-2
Human
ELISA WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody (aa348-377) LS-C324510

Rabbit Polyclonal (IgG) to Human RAG2 / RAG-2
Mouse, Human
ELISA Flo IHC WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody LS-C334173

Rabbit Polyclonal (IgG) to Human RAG2 / RAG-2
Rat, Human
IF IHC WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody LS-C482475

Rabbit Polyclonal to Human RAG2 / RAG-2
Mouse, Rat, Human
ICC IF WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody (aa271-527) LS-C186092

Rabbit Polyclonal (IgG) to Human RAG2 / RAG-2
Human
ICC IHC-P WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody LS-C341675

Rabbit Polyclonal to Human RAG2 / RAG-2
Mouse, Rat, Human
IF WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody LS-C490468

Rabbit Polyclonal (IgG) to Human RAG2 / RAG-2
Mouse, Rat, Human
IHC-P WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody (clone 2G8) LS-C198057

Mouse Monoclonal [clone 2G8] (IgG2b,k) to Human RAG2 / RAG-2
Rat, Human
ELISA WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody (C-Terminus) LS-C145992

Rabbit Polyclonal to Human RAG2 / RAG-2
Dog, Bovine, Pig, Human
WB
Unconjugated
Anti-RAG2 / RAG-2 Antibody (C-Terminus, HRP) LS-C468307

Rabbit Polyclonal to Human RAG2 / RAG-2
Dog, Bovine, Pig, Gibbon, Human
WB
HRP Conjugated
Anti-RAG2 / RAG-2 Antibody (C-Terminus, Biotin) LS-C468305

Rabbit Polyclonal to Human RAG2 / RAG-2
Dog, Bovine, Pig, Gibbon, Human
WB
Biotin Conjugated
Anti-RAG2 / RAG-2 Antibody (C-Terminus, FITC) LS-C468306

Rabbit Polyclonal to Human RAG2 / RAG-2
Dog, Bovine, Pig, Gibbon, Human
WB
FITC Conjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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