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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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We could not find product '(ID:670705)'. Here are some alternate products to this target that might be of interest to you.



RAF1 / RAF

v-raf-1 murine leukemia viral oncogene homolog 1

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.

Gene Name: v-raf-1 murine leukemia viral oncogene homolog 1
Family/Subfamily: Protein Kinase , Raf
Synonyms: RAF1, C-Raf, C-raf-1, CRAF, NS5, Raf-1, Proto-oncogene c-RAF, Oncogene RAF1, RAF, Raf1 kinase
Target Sequences: NM_002880 NP_002871.1 P04049

Publications (1)

1
PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway. Yu C, Han W, Shi T, Lv B, He Q, Zhang Y, Li T, Zhang Y, Song Q, Wang L, Ma D. Cellular signalling. 2008 20:2208-20. (IP) [PubMed:18771726]

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No (301)
Viewing 1-25 of 301 items
RAF1 / RAF Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Mouse RAF1 / RAF
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200µl   $425.00
RAF1 / RAF Antibody - Anti-RAF1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Mouse Monoclonal (IgG1,k) to Human RAF1 / RAF
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
RAF1 / RAF Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human RAF1 / RAF
Chicken, Bovine, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
RAF1 / RAF Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Rabbit Polyclonal to Human RAF1 / RAF
Human
Flo, IF, IHC, WB
Unconjugated
400µl   $325.00
RAF1 / RAF Antibody - IHC of paraffin-embedded liver cancer tissues using RAF1 mouse monoclonal antibody with DAB staining.
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Mouse Monoclonal [clone 4G4] (IgG1) to Human RAF1 / RAF
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100µg   1mg/ml   $365.00
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Rat Monoclonal [clone pS338 (DPR/2/2A/3A)] (IgG1) to Human RAF1 / RAF
Human
WB
Unconjugated
0.1mg   $395.00
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Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
RAF1 / RAF Antibody - Immunohistochemistry of Raf-1 antibody
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Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Human
IHC, WB
Unconjugated
50µl   $235.00; 100µl   $265.00; 200µl   $335.00
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Rabbit Polyclonal to Human RAF1 / RAF
Human, Monkey
IP, WB
Unconjugated
100µl   $530.00
RAF1 / RAF Antibody
Select
Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
RAF1 / RAF Antibody - Western blot of Phospho-RAF1-pS338 Antibody in human TPA activated HeLa cell line lysates. Phospho-RAF1 (arrow) was detected using the purified antibody. (0: without TPA; 1: 60 ug/ml TPA, 15min; 2: 60 ug/ml TPA, 30min; 3: 60 ug/ml TPA, 45min; 4: 125 ug/ml TPA, 15min; 5: 125 ug/ml TPA, 30min; 6: 125 ug/ml TPA, 45min; 7: 250 ug/ml TPA, 15min; 8: 250 ug/ml TPA, 30min; 9: 250 ug/ml, 45min)
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Rabbit Polyclonal to Human RAF1 / RAF
Human
DB, WB
Unconjugated
400µl   $325.00
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Sheep Polyclonal (IgG) to Human RAF1 / RAF
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Bat, Human, Monkey
IP, WB
Unconjugated
100µg   $435.00
RAF1 / RAF Antibody - IHC of paraffin-embedded bladder cancer tissues using RAF1 mouse monoclonal antibody with DAB staining.
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Mouse Monoclonal [clone 4G4] (IgG1) to Human RAF1 / RAF
Human
ELISA, Flo, IHC, WB
Unconjugated
100µg   1mg/ml   $365.00
RAF1 / RAF Antibody
Select
Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
RAF1 / RAF Antibody
Select
Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
RAF1 / RAF Antibody - Western blot of recombinant RAF1 / RAF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human RAF1 / RAF
Human
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $530.00
RAF1 / RAF Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using Raf1 (Phospho-Ser621) antibody.
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Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $305.00
RAF1 / RAF Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using Raf1 (Ab-621) antibody.
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Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $305.00
Select
Rabbit Monoclonal (IgG) to Human RAF1 / RAF
Mouse, Rat, Human, Monkey
WB
Unconjugated
100µl   $575.00
RAF1 / RAF Antibody - Western blot of C-RAF expression in UV treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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Rabbit Polyclonal to Human RAF1 / RAF
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100µg   $305.00
RAF1 / RAF Antibody - Western blot of C-RAF phosphorylation expression in UV treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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Rabbit Polyclonal to Human RAF1 / RAF
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100µg   $305.00
Select
Rabbit Polyclonal (IgG) to Mouse RAF1 / RAF
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200µl   $590.00
Select
Mouse Monoclonal (IgG1) to Human RAF1 / RAF
Human
ELISA, Flo, IHC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
Select
Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human RAF1 / RAF
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $355.00

Viewing 1-25 of 301 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).