RAD9A / RAD9

RAD9 homolog A (S. pombe)

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

RAD9A / RAD9 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human RAD9A / RAD9 Protein (Recombinant GST, N-terminus) (aa61-170) - LS-G59854

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RAD9A / RAD9 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67835

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

20 µg/$1,107

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Human RAD9A / RAD9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80812

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

20 µg/$150

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RAD9A / RAD9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100334

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.4 kDa

Price:

100 µg/$494

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