RAD51B

RAD51 paralog B

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RAD51B (5)

Publications

No (5)

Tag

GST (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human RAD51B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81885

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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Human RAD51B Protein (Recombinant GST) (Full Length) - LS-G30094

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.6 kDa

Price:

10 µg/$479; 25 µg/$670

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RAD51B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107475

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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Human RAD51B Protein (Recombinant His, N-Terminal) - LS-G144299

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

42 kDa

Price:

50 µg/$419

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Human RAD51B Protein (Recombinant His) - LS-G2682

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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