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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RAD51B

RAD51 paralog B

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.

Gene Name: RAD51 paralog B
Synonyms: RAD51B, HREC2, RAD51-like 1 (S. cerevisiae), RAD51L1, RAD51-like protein 1, Recombination repair protein, REC2, RecA-like protein, R51H2, RAD51 (S. cerevisiae)-like 1, RAD51 homolog B
Target Sequences: NM_002877 NP_002868.1 O15315

Publications (1)

1
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Blood. 2009 113:2290-7. [PubMed:19050310] [PMC:PMC2652372]

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Viewing 1-6 of 6 items
RAD51B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc + DDK
42 kDa
20µg   $195.00
RAD51B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
42 kDa
100µg   $365.00
RAD51B Protein
Select
E. coli
His, N-Terminal
42 kDa
50µg   $325.00
RAD51B Protein - 12.5% SDS-PAGE of human RAD51L1 stained with Coomassie Blue
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Wheat Germ Extract
GST
68.6 kDa
10µg   $425.00; 25µg   $590.00
RAD51B Protein
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E. coli
His
100µg   1mg/ml   $315.00; 0.5mg   1mg/ml   $695.00
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E. coli
His
40.6 kDa
5µg   $195.00; 20µg   $255.00; 1mg   $2,850.00

Viewing 1-6 of 6 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).