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RAD23A / HHR23A

RAD23 homolog A (S. cerevisiae)

Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

Gene Name: RAD23 homolog A (S. cerevisiae)
Synonyms: RAD23A, HR23A, HHR23A, RAD23, yeast homolog, A
Target Sequences: NM_005053 NP_005044.1 P54725

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
RAD23A / HHR23A (7)
No (7)
GST (1)
GST, N-terminus (2)
His (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
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E. coli
GST, N-terminus
67 kD
1 mg/$1,207; 100 µg/$408; 20 µg/$311
RAD23A / HHR23A Protein
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Yeast
His
41.6 kD
1 mg/$1,342; 100 µg/$436; 20 µg/$326
RAD23A / HHR23A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$469; 25 µg/$630
RAD23A / HHR23A Protein - Purified recombinant protein RAD23A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$1,005
RAD23A / HHR23A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.4 kDa
20 µg/$130
RAD23A / HHR23A Protein - 12.5% SDS-PAGE of human RAD23A stained with Coomassie Blue
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Wheat Germ Extract
GST
66 kDa
10 µg/$469; 25 µg/$630
RAD23A / HHR23A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.4 kDa
100 µg/$458
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).