RAD21

RAD21 homolog (S. pombe)

Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

RAD21 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human RAD21 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80893

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.5 kDa

Price:

20 µg/$150

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Human RAD21 Protein (Recombinant GST) (Full Length) - LS-G30089

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

98.1 kDa

Price:

2 µg/$439

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RAD21 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100771

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.5 kDa

Price:

100 µg/$494

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