RAD17

RAD17 homolog (S. pombe)

RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

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ELISA Kits (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Target

RAD17 (2)

Reactivity

Human (2)

Mouse (2)

Format

96-Well Microplate (2)

Publications

No (2)

Sample Type

Adherent Cell Cultures (2)

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Mouse/Human RAD17 (Cell-Based ELISA) ELISA Kit - LS-F2278

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse/Human Phospho-RAD17 (Ser645) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1099

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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