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Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.
Gene Name: | Ras-related C3 Botulinum Toxin Substrate 3 (rho Family, Small GTP Binding Protein Rac3) |
Family/Subfamily: | Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806 |
Synonyms: | RAC3, p21-Rac3 |
Target Sequences: | NM_005052 NP_005043.1 P60763 |
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