RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

☰ Filters

Products

Proteins (13)

Type

Over-Expression Lysate (5)

Recombinant (8)

Target

RAC1 (13)

Publications

No (13)

Tag

6His, N-terminus (1)

GST (2)

His (1)

His-S (1)

Myc-DDK (Flag) (7)

Species

Human (11)

Source

293T Cells (3)

Baculovirus (1)

E. coli (4)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

Select

Human RAC1 Protein (Recombinant His) - LS-G625

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

Select

Human RAC1 Protein (Recombinant) - LS-G3537

Source:

E. coli

Tag:

None

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

Select

Human RAC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66812

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

20 µg/$1,107

Select

Human RAC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66814

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.3 kDa

Price:

20 µg/$1,107

Select

Human RAC1 Protein (Recombinant GST) (Met1-Cys189) - LS-G97816

Source:

Baculovirus

Tag:

GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47 kDa

Price:

50 µg/$854

Select

Human RAC1 Protein (Recombinant GST) (Full Length) - LS-G30084

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.86 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human RAC1 Protein (Recombinant 6His, N-terminus) (Gln2-Cys189) - LS-G26514

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

23 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949

Select

Human RAC1 Protein (Recombinant His-S) (aa1-189) - LS-G26181

Source:

E. coli

Tag:

His-S

Molecular Weight:

24.8 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

Select

RAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111586

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

100 µg/$494

Select

Human RAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78537

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.3 kDa

Price:

20 µg/$150

Select

Human RAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78538

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

20 µg/$150

Select

Human RAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78539

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.3 kDa

Price:

20 µg/$150

Select

RAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114993

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.3 kDa

Price:

100 µg/$494

Viewing 1-13 of 13 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.