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RAB29 / RAB7L1
RAB7, member RAS oncogene family-like 1
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.
| Gene Name: | RAB7, member RAS oncogene family-like 1 |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , RAS oncogene |
| Synonyms: | RAB29, RAB7L, Ras-related protein Rab-7L1, Rab-7-like protein 1, RAB7L1 |
| Target Sequences: | NM_003929 NP_003920.1 O14966 |
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