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RAB14
RAB14, member RAS oncogene family
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.
| Gene Name: | RAB14, member RAS oncogene family |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , RAS oncogene |
| Synonyms: | RAB14, F protein-binding protein 1, FBP, RAB-14, Ras-related protein Rab-14 |
| Target Sequences: | NM_016322 NP_057406.2 P61106 |
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