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The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.
Gene Name: | RAB12, member RAS oncogene family |
Synonyms: | RAB12, Ras-related protein Rab-12 |
Target Sequences: | NM_001025300 NP_001020471.2 Q6IQ22 |
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