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RAB11FIP2 / Rab11-FIP2
RAB11 family interacting protein 2 (class I)
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
| Gene Name: | RAB11 family interacting protein 2 (class I) |
| Synonyms: | RAB11FIP2, KIAA0941, NRip11, Rab11-FIP2, RAB11-FIP2 long isoform |
| Target Sequences: | NM_014904 NP_055719.1 Q7L804 |
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