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QPCT / QC
glutaminyl-peptide cyclotransferase
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
| Gene Name: | glutaminyl-peptide cyclotransferase |
| Family/Subfamily: | Protease , Metallopeptidase M28 |
| Synonyms: | QPCT, EC, Glutaminyl cyclase, Glutamyl cyclase, GCT, QC, SQC |
| Target Sequences: | NM_012413 NP_036545.1 Q16769 |
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