Pyrin / MEFV / MEF

Mediterranean fever

Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimately induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (PubMed:16037825). Has also been shown to inhibit IL1B production (PubMed:16785446, PubMed:17431422). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization.

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Products

ELISA Kits (5)

Type

Custom (2)

Sandwich (3)

Target

Pyrin / MEFV / MEF (5)

Reactivity

Human (3)

Mouse (1)

Rat (1)

Format

96-Well Strip Plate (5)

Publications

No (5)

Sample Type

Plasma (3)

Serum (3)

Tissue Homogenates (1)

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Human Pyrin / MEFV / MEF (Sandwich ELISA) ELISA Kit - LS-F33871

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat Pyrin / MEFV / MEF (Custom ELISA) ELISA Kit - LS-F19242

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse Pyrin / MEFV / MEF (Custom ELISA) ELISA Kit - LS-F19243

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human Pyrin / MEFV / MEF (Sandwich ELISA) ELISA Kit - LS-F55001

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$834

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Human Pyrin / MEFV / MEF (Sandwich ELISA) ELISA Kit - LS-F12024

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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