PYGL

phosphorylase, glycogen, liver

PYGL is a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

PYGL (12)

Publications

No (12)

Tag

GST (2)

His (7)

Myc-DDK (Flag) (3)

Species

Human (8)

Rat (3)

Source

293T Cells (1)

E. coli (7)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (3)

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Human PYGL Protein (Recombinant GST) (Full Length) - LS-G21104

Source:

E. coli

Tag:

GST

Molecular Weight:

124.2 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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PYGL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117711

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97 kDa

Price:

100 µg/$494

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Human PYGL Protein (Recombinant GST) (Full Length) - LS-G30064

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

123.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PYGL Protein (Recombinant His) (Full Length) - LS-G23097

Source:

Yeast

Tag:

His

Molecular Weight:

98.8 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human PYGL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76235

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97 kDa

Price:

20 µg/$150

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Human PYGL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65762

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97 kDa

Price:

20 µg/$1,107

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Human PYGL Protein (Recombinant His) - LS-G3278

Source:

E. coli

Tag:

His

Price:

10 µg/$279; 50 µg/$373; 20 µg/$329; 100 µg/$479; 250 µg/$769; 500 µg/$1,243

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Human PYGL Protein (Recombinant His) (aa633-820) - LS-G12978

Source:

E. coli

Tag:

His

Molecular Weight:

22.6 kDa

Price:

10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562

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Rat PYGL Protein (Recombinant His) (aa73-267) - LS-G12981

Source:

E. coli

Tag:

His

Molecular Weight:

23.6 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human PYGL Protein (Recombinant His) (aa370-538) - LS-G12977

Source:

E. coli

Tag:

His

Molecular Weight:

21.0 kDa

Price:

10 µg/$307; 50 µg/$602; 100 µg/$962; 200 µg/$1,156; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562

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Rat PYGL Protein (Recombinant His) (aa603-750) - LS-G12980

Source:

E. coli

Tag:

His

Molecular Weight:

17.4 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Rat PYGL Protein (Recombinant His) (aa341-509) - LS-G12979

Source:

E. coli

Tag:

His

Molecular Weight:

21.0 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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