Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
|Gene Name:||PYD (pyrin domain) containing 1|
|Synonyms:||PYDC1, PYC1, Pyrin-only protein 1, Pyrin domain containing 1, ASC2, ASCI, PAAD-only protein 1|
|Target Sequences:||Q8WXC3 Q8WXC3|
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