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PXN / Paxillin

paxillin

PXN / Paxillin is a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).

Gene Name:	paxillin
Synonyms:	PXN, Paxillin
Target Sequences:	NM_002859 NP_002850.2 P49023

Publications (3)

RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility. Yao H, Dashner EJ, van Golen CM, van Golen KL. Oncogene. 2006 25:2285-96. [PubMed:16314838]

GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. Schmalzigaug R, Garron ML, Roseman JT, Xing Y, Davidson CE, Arold ST, Premont RT. Cellular signalling. 2007 19:1733-44. (ICC, IP) [PubMed:17467235] [PMC:PMC2025689]

Podosomes are present in a postsynaptic apparatus and participate in its maturation. Proszynski TJ, Gingras J, Valdez G, Krzewski K, Sanes JR. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:18373-8. [PubMed:19822767] [PMC:PMC2775295]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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