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PVRL4 / Nectin 4

poliovirus receptor-related 4

PVRL4 / Nectin 4 is a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Gene Name: poliovirus receptor-related 4
Synonyms: PVRL4, EDSS1, Nectin 4, Ig superfamily receptor LNIR, Poliovirus receptor-like 4, LNIR, Nectin-4, Poliovirus receptor-related 4
Target Sequences: NM_030916 NP_112178.2 Q96NY8

Publications (1)

1
Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Mhlebach MD, Mateo M, Sinn PL, Prfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray PB, Cichutek K, von Messling V, Lopez M, Cattaneo R. Nature. 2011 480:530-3. (Flo; Human) [Full Text Article] [PubMed:22048310] [PMC:PMC3245798] Related Antibodies: LS-C37483.

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Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
PVRL4 / Nectin 4 (11)
No (11)
6His, C-terminus (3)
Fc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (2)
Myc-DDK (Flag) (3)
Human (8)
Mouse (1)
Poliovirus (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Human (1)
Human Cells (1)
Mammalian Cells (2)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
Low endotoxin level (4)
Biologically active (1)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.3kD
10 µg/$277; 50 µg/$395; 500 µg/$1,203
PVRL4 / Nectin 4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PVRL4 / Nectin 4 Protein - Purified recombinant protein NECTIN4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
55.3 kDa
20 µg/$1,107
PVRL4 / Nectin 4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
55.3 kDa
20 µg/$150
PVRL4 / Nectin 4 Protein - 12.5% SDS-PAGE of human PVRL4 stained with Coomassie Blue
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Wheat Germ Extract
GST
81.9 kDa
2 µg/$439
PVRL4 / Nectin 4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
55.3 kDa
100 µg/$494
PVRL4 / Nectin 4 Protein - Recombinant Mouse Nectin-4 (C-Fc)
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Human
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
61.4kDa
10 µg/$286; 50 µg/$362
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.3 kDa
10 µg/$277; 50 µg/$389
PVRL4 / Nectin 4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.3 kDa
50 µg/$453; 10 µg/$298; 1 mg/$2,064; 500 µg/$1,470
PVRL4 / Nectin 4 Protein - Recombinant Poliovirus Receptor Related Protein 4 By SDS-PAGE
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E. coli
His
34.5 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,441
PVRL4 / Nectin 4 Protein
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Yeast
His
36.1 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).