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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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PVRL3 / Nectin-3
poliovirus receptor-related 3
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
| Gene Name: | poliovirus receptor-related 3 |
| Synonyms: | PVRL3, CDW113, DKFZP566B0846, Nectin 3, PPR3, Poliovirus receptor-related 3, CD113, CD113 antigen, NECTIN-3, PVRR3 |
| Target Sequences: | NM_015480 NP_056295.1 Q9NQS3 |
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