PUF60

poly-U binding splicing factor 60KDa

DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.

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Products

Antibodies (41)

Proteins (10)

ELISA Kits (1)

Type

Development Kit (1)

Over-Expression Lysate (4)

Primary (41)

Recombinant (6)

Target

PUF60 (52)

Reactivity

Human (42)

Mouse (15)

Rat (13)

Bovine (10)

Chicken (7)

Chimpanzee (9)

Dog (10)

Gibbon (9)

Guinea pig (9)

Hamster (1)

Horse (10)

Monkey (10)

Orangutan (6)

Xenopus (7)

Zebrafish (7)

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IHC (21)

IHC-P (15)

WB (38)

ELISA (11)

ICC (2)

IF (4)

IP (5)

Peptide-ELISA (1)

Host

rabbit (40)

goat (1)

Product Group

DevKit DuoPlus (1)

IHCPlus (3)

Isotype

IgG (28)

Clonality

polyclonal pc (41)

Format

Antibody Pair and Standard (1)

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (6)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (6)

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PE Conjugated (2)

Unconjugated (17)

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Epitope

C-Terminus (8)

aa15-43 (7)

aa371-420 (4)

N-Terminus (1)

aa1-50 (1)

aa346-523 (1)

aa400-450 (1)

aa509-559 (1)

aa530-542 (1)

Publications

No (52)

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Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (1)

Serum (1)

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Tag

GST (2)

GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

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Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (3)

Select

IHC-plus™ PUF60 Antibody (aa346-523) LS-B10758

(4.0) Rating

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa346-523) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

PUF60 Antibody (aa371-420) LS-C80370

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa371-420) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$397

Select

PUF60 Antibody (aa371-420, HRP) LS-C440886

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa371-420) (HRP) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$442

Select

PUF60 Antibody (aa371-420, Biotin) LS-C440884

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa371-420) (Biotin) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$442

Select

PUF60 Antibody (aa371-420, FITC) LS-C440885

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa371-420) (FITC) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PUF60 Antibody LS-C482684

Antibody:

PUF60 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

Select

IHC-plus™ PUF60 Antibody (aa530-542) LS-B15938

(4.0) Rating

Antibody:

PUF60 Goat anti-Human Polyclonal (aa530-542) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Horse, Bovine, Mouse, Dog, Rat, Hamster, Human, Monkey

Applications:

IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$460

Select

PUF60 Antibody LS-C334895

Antibody:

PUF60 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

PUF60 Antibody LS-C755043

Antibody:

PUF60 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

PUF60 Antibody (C-Terminus) LS-B12600

Antibody:

PUF60 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

PUF60 Antibody (C-Terminus, HRP) LS-C441043

Antibody:

PUF60 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PUF60 Antibody (C-Terminus, Biotin) LS-C441040

Antibody:

PUF60 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PUF60 Antibody (C-Terminus, FITC) LS-C441042

Antibody:

PUF60 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PUF60 Antibody LS-C769986

Antibody:

PUF60 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

PUF60 Antibody (aa1-50) LS-C289530

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

PUF60 Antibody (aa400-450) LS-C289531

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa400-450) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

PUF60 Antibody (C-Terminus) LS-C80372

Antibody:

PUF60 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$397

Select

PUF60 Antibody (C-Terminus, HRP) LS-C441046

Antibody:

PUF60 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$442

Select

PUF60 Antibody (C-Terminus, Biotin) LS-C441045

Antibody:

PUF60 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$442

Select

PUF60 Antibody (C-Terminus, FITC) LS-C441044

Antibody:

PUF60 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PUF60 Antibody (N-Terminus) LS-C144670

Antibody:

PUF60 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

Select

PUF60 Antibody (aa509-559) LS-C289536

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa509-559) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

PUF60 Antibody (aa15-43) LS-C324426

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa15-43) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PUF60 Antibody (aa15-43, APC) LS-C267590

Antibody:

PUF60 Rabbit anti-Human Polyclonal (aa15-43) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• APC

• Unconjugated
• APC

Select

PUF60 Antibody LS-C501985

Antibody:

PUF60 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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