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PTPRN2 / Phogrin
protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRN2 / Phogrin is a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.
| Gene Name: | protein tyrosine phosphatase, receptor type, N polypeptide 2 |
| Family/Subfamily: | Protein Phosphatase , R8 |
| Synonyms: | PTPRN2, ICAAR, Ia-2 beta, IA-2beta, PTPRP, R-PTP-N2, Phogrin, Ptp-np, IAR, KIAA0387, PTP NE-6, Tyrosine phosphatase IA-2 beta |
| Target Sequences: | NM_002847 NP_002838.2 Q92932 |
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