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PTPRH / SAP-1

protein tyrosine phosphatase, receptor type, H

May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.

Gene Name: protein tyrosine phosphatase, receptor type, H
Family/Subfamily: Protein Phosphatase , R3
Synonyms: PTPRH, SAP-1, R-PTP-H, PTP sap-1, SAP1
Target Sequences: NM_002842

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
PTPRH / SAP-1 (6)
No (6)
His-T7 (3)
Myc-DDK (Flag) (3)
Human (3)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
PTPRH / SAP-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
122.2 kDa
100 µg/$710
PTPRH / SAP-1 Protein - Recombinant  Protein Tyrosine Phosphatase Receptor Type H By SDS-PAGE
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E. coli
His-T7
32.6 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
PTPRH / SAP-1 Protein - Purified recombinant protein PTPRH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
122.2 kDa
20 µg/$1,107
PTPRH / SAP-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
122.2 kDa
20 µg/$215
PTPRH / SAP-1 Protein - Recombinant Protein Tyrosine Phosphatase Receptor Type H By SDS-PAGE
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E. coli
His-T7
33.0 kDa
50 µg/$422; 10 µg/$278; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
PTPRH / SAP-1 Protein - Recombinant Protein Tyrosine Phosphatase Receptor Type H By SDS-PAGE
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E. coli
His-T7
29.7 kDa
50 µg/$442; 10 µg/$281; 200 µg/$882; 100 µg/$705; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).