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PTPRG / RPTR-Gamma
protein tyrosine phosphatase, receptor type, G
PTPRG / RPTR-Gamma is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
| Gene Name: | protein tyrosine phosphatase, receptor type, G |
| Family/Subfamily: | Protein Phosphatase , R5 |
| Synonyms: | PTPRG, H_RG317H01.1, HPTPG, PTPG, Ptpgamma, RPTPG, PTP gamma, R-PTP-GAMMA |
| Target Sequences: | NM_002841 NP_002832.3 P23470 |
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