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PTPN6 / SHP1

protein tyrosine phosphatase, non-receptor type 6

PTPN6 / SHP1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Gene Name: protein tyrosine phosphatase, non-receptor type 6
Family/Subfamily: Protein Phosphatase , NT2
Synonyms: PTPN6, HCP, HPTP1C, Hematopoietic cell phosphatase, PTP-1C, SH-PTP1, SHP-1L, SHP-1, Shptp1, HCPH, PTP1C, SHP1
Target Sequences: NM_002831 NP_002822.2 P29350

Publications (3)

1
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70. Chen Z, Chen L, Qiao SW, Nagaishi T, Blumberg RS. Journal of immunology (Baltimore, Md. : 1950). 2008 180:6085-93. (IP) [PubMed:18424730]
2
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Darienne R Myers, Clare L Abram, David Wildes, Amira Belwafa, Alia M N Welsh, Christopher J Schulze, Tiffany J Choy, Tram Nguyen, Neil Omaque, Yongmei Hu, Mallika Singh, Rich Hansen, Mark A Goldsmith, Elsa Quintana, Jacqueline A M Smith, Clifford A Lowell. Frontiers in immunology. 2020 November;11:576310. [Full Text Article] [PubMed:33133093] [PMC:PMC7550718] Related Antibodies: LS-C358839.
3
Inhibitory affinity modulation of Fc?RIIA ligand binding by glycosphingolipids by inside-out signaling. Koshu Okubo, Michael D Brenner, Xavier Cullere, Gurpanna Saggu, Myra L Patchen, Nandita Bose, Saki Mihori, Zhou Yuan, Clifford A Lowell, Cheng Zhu, Tanya N Mayadas. Cell reports. 2021 May;35:109142. [Full Text Article] [PubMed:34010642] [PMC:PMC8218468] Related Antibodies: LS-C358839.

☰ Filters
Products
Proteins (15)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (9)
PTPN6 / SHP1 (15)
No (15)
6His, C-terminus (2)
6His, N-terminus (2)
GST (1)
His (1)
His/GST,N-terminus (1)
His-SUMO (1)
Myc-DDK (Flag) (6)
Human (12)
Mouse (1)
293T Cells (2)
E. coli (5)
HEK 293 Cells (6)
Insect Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (4)
Biologically active (1)
PTPN6 / SHP1 Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$411; 500 µg/$985; 20 µg/$276
Select
HEK 293 Cells
6His, N-terminus
70 kDa
100 µg/$298
PTPN6 / SHP1 Protein - Purified recombinant protein PTPN6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
67.4 kDa
20 µg/$1,107
PTPN6 / SHP1 Protein - Purified recombinant protein PTPN6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
67.5 kDa
20 µg/$1,107
PTPN6 / SHP1 Protein
Select
E. coli
His-SUMO
83.7 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PTPN6 / SHP1 Protein - Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 6 By SDS-PAGE
Select
E. coli
His
34.9 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
PTPN6 / SHP1 Protein - 12.5% SDS-PAGE of human PTPN6 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
91.19 kDa
10 µg/$479; 25 µg/$670
Select
HEK 293 Cells
6His, N-terminus
70 kDa
200 µl/$283
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.38kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
PTPN6 / SHP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
67.5 kDa
100 µg/$494
PTPN6 / SHP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
67.4 kDa
100 µg/$494
Select
Insect Cells
His/GST,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
72.7 kDa
100 µg/$843
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.4 kDa
10 µg/$344; 50 µg/$584
PTPN6 / SHP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
67.4 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
67.5 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).