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PTPN5 / STEP

protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)

Striatum-enriched phosphatase, a R7 receptor protein tyrosine phosphatase, is a component of the NMDAR complex and has been suggested affect the development and maturation of the striatal neurons. STEP has been shown to regulate the activity of Fyn and may be one mechanism by which Fyn activity is decreased within the postsynaptic densities (PSDs) of striatal neurons. Alternative splicing of STEP produces cytosolic, transmembrane, and truncated isoforms. Three alternatively spliced isoforms have been isolated: Step46 - a cytosolic form, Step61 - a membrane form containing 172 additional amino acids in the N terminus when compared to Step46, and Step20 which lacks the tyrosine phosphatase domain.

Gene Name:	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
Family/Subfamily:	Protein Phosphatase , R7 receptor
Synonyms:	PTPN5, Striatal enriched phosphatase, Striatum enriched phosphatase, PTPSTEP, STEP
Target Sequences:	NM_006906 AAA87555.1 P54829

Publications (20)

Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase. Boulanger LM, Lombroso PJ, Raghunathan A, During MJ, Wahle P, Naegele JR. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1995 15:1532-44. [PubMed:7869116]

STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum. Bult A, Zhao F, Dirkx R, Sharma E, Lukacsi E, Solimena M, Naegele JR, Lombroso PJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1996 16:7821-31. (WB, IHC-Fr) [PubMed:8987810]

Hypoxia-ischemia in perinatal rat brain induces the formation of a low molecular weight isoform of striatal enriched tyrosine phosphatase (STEP). Gurd JW, Bissoon N, Nguyen TH, Lombroso PJ, Rider CC, Beesley PW, Vannucci SJ. Journal of neurochemistry. 1999 73:1990-4. [PubMed:10537057]

Calcium-dependent cleavage of striatal enriched tyrosine phosphatase (STEP). Nguyen TH, Paul S, Xu Y, Gurd JW, Lombroso PJ. Journal of neurochemistry. 1999 73:1995-2001. [PubMed:10537058]

Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation. Pelkey KA, Askalan R, Paul S, Kalia LV, Nguyen TH, Pitcher GM, Salter MW, Lombroso PJ. Neuron. 2002 34:127-38. [PubMed:11931747]

Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420. Nguyen TH, Liu J, Lombroso PJ. The Journal of biological chemistry. 2002 277:24274-9. (WB) [PubMed:11983687]

NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Paul S, Nairn AC, Wang P, Lombroso PJ. Nature neuroscience. 2003 6:34-42. (WB, IP) [PubMed:12483215]

Status epilepticus-induced somatostatinergic hilar interneuron degeneration is regulated by striatal enriched protein tyrosine phosphatase. Choi YS, Lin SL, Lee B, Kurup P, Cho HY, Naegele JR, Lombroso PJ, Obrietan K. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:2999-3009. [PubMed:17360923] [PMC:PMC2701360]

Translation of striatal-enriched protein tyrosine phosphatase (STEP) after beta1-adrenergic receptor stimulation. Hu Y, Zhang Y, Venkitaramani DV, Lombroso PJ. Journal of neurochemistry. 2007 103:531-41. (WB, IHC-Fr) [PubMed:17623046] [PMC:PMC2679031]

Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons. Zhao M, Choi YS, Obrietan K, Dudek SM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:12025-32. [PubMed:17978044]

The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation. Zhang Y, Venkitaramani DV, Gladding CM, Zhang Y, Kurup P, Molnar E, Collingridge GL, Lombroso PJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:10561-6. [PubMed:18923032] [PMC:PMC2586105]

Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices. Goebel-Goody SM, Davies KD, Alvestad Linger RM, Freund RK, Browning MD. Neuroscience. 2009 158:1446-59. [PubMed:19041929]

A role for calmodulin-stimulated adenylyl cyclases in cocaine sensitization. DiRocco DP, Scheiner ZS, Sindreu CB, Chan GC, Storm DR. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 29:2393-403. [PubMed:19244515] [PMC:PMC2678191]

Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 30:5948-57. (WB) [PubMed:20427654] [PMC:PMC2868326]

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:19014-9. [PubMed:20956308] [PMC:PMC2973892]

NR2B-NMDA receptor mediated modulation of the tyrosine phosphatase STEP regulates glutamate induced neuronal cell death. Poddar R, Deb I, Mukherjee S, Paul S. Journal of neurochemistry. 2010 115:1350-62. (WB; Rat) [PubMed:21029094] [PMC:PMC3035421]

Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP. Mukherjee S, Poddar R, Deb I, Paul S. The Biochemical journal. 2011 440:115-25. [PubMed:21777200] [PMC:PMC3408964]

Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits. Davis MM, Olausson P, Greengard P, Taylor JR, Nairn AC. The European journal of neuroscience. 2012 35:300-8. (WB; Mouse) [PubMed:22250817]

GluA2 AMPA glutamate receptor subunit exhibits codon 607 Q/R RNA editing in the lens. Farooq M, Kaswala RH, Kleiman NJ, Kasinathan C, Frederikse PH. Biochemical and biophysical research communications. 2012 418:273-7. [PubMed:22266371] [PMC:PMC3351098]

Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents. Shinohara Y, Hosoya A, Yahagi K, Ferecsk AS, Yaguchi K, Sk A, Itakura M, Takahashi M, Hirase H. The European journal of neuroscience. 2012 35:702-10. [PubMed:22339771]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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