PTPN22 / PEP

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

PTPN22 / PEP (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-T7, N-terminus (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human PTPN22 / PEP Protein (Recombinant GST) (Full Length) - LS-G33116

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

45.43 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PTPN22 / PEP Protein (Recombinant GST, N-terminus) (aa10-113) - LS-G62154

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PTPN22 / PEP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88802

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.5 kDa

Price:

20 µg/$215

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Human PTPN22 / PEP Protein (Recombinant His-T7, N-terminus) (Met1-Arg233) - LS-G133388

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

31.1kDa

Price:

10 µg/$268; 50 µg/$362; 200 µg/$722; 100 µg/$577; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Rat PTPN22 / PEP Protein (Recombinant His-T7, N-terminus) (Met1-Phe256) - LS-G133594

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

33.8kDa

Price:

10 µg/$275; 50 µg/$402; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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PTPN22 / PEP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112947

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

91.5 kDa

Price:

100 µg/$710

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