PTPN2 / TC-PTP

protein tyrosine phosphatase, non-receptor type 2

Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.

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Products

Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

PTPN2 / TC-PTP (11)

Publications

No (11)

Tag

GST (1)

His,N-terminus (1)

His,N-terminus + GST (1)

His-T7, N-terminus (2)

Myc-DDK (Flag) (5)

Species

Human (7)

Mouse (2)

Source

293T Cells (2)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (3)

Insect Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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Human PTPN2 / TC-PTP Protein (Recombinant His,N-terminus + GST) (Met1-Asn314) - LS-G138080

Source:

Insect Cells

Tag:

His,N-terminus + GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

64.4 kDa

Price:

100 µg/$926

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Mouse PTPN2 / TC-PTP Protein (Recombinant His,N-terminus) (Ser2-Asn314) - LS-G138138

Source:

Insect Cells

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

38.7 kDa

Price:

100 µg/$926

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PTPN2 / TC-PTP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107873

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.8 kDa

Price:

100 µg/$494

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PTPN2 / TC-PTP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117742

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.3 kDa

Price:

100 µg/$494

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Human PTPN2 / TC-PTP Protein (Recombinant GST) (Full Length) - LS-G30034

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PTPN2 / TC-PTP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67063

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.8 kDa

Price:

20 µg/$1,107

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Human PTPN2 / TC-PTP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79039

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.3 kDa

Price:

20 µg/$150

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Human PTPN2 / TC-PTP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79040

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.8 kDa

Price:

20 µg/$150

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Human PTPN2 / TC-PTP Protein (Recombinant) (Met1-Asn314) - LS-G98646

Source:

Baculovirus

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36.8 kDa

Price:

100 µg/$926

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Mouse PTPN2 / TC-PTP Protein (Recombinant His-T7, N-terminus) (Met1-Glu237) - LS-G133514

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

31.3kDa

Price:

10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human PTPN2 / TC-PTP Protein (Recombinant His-T7, N-terminus) (Met1-Gly257) - LS-G133389

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

33.7kDa

Price:

10 µg/$268; 50 µg/$360; 200 µg/$717; 100 µg/$575; 1 mg/$1,748; 500 µg/$1,318; 5 mg/$2,701; 2 mg/$1,927

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