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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PTPN2 / TC-PTP

protein tyrosine phosphatase, non-receptor type 2

Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.

Gene Name: protein tyrosine phosphatase, non-receptor type 2
Family/Subfamily: Protein Phosphatase , NT1
Synonyms: PTPN2, PTN2, TC-PTP, TCELLPTP, PTPT, Tc45, TC48, TCPTP
Target Sequences: NM_002828 NP_002819.2 P17706

Filtered By: None
Target
PTPN2 / TC-PTP (39)
Reactivity
Human (35)
Mouse (25)
Rat (16)
Bovine (8)
Chicken (8)
Chimpanzee (9)
Dog (5)
Gibbon (9)
Guinea pig (12)
Hamster (1)
Horse (12)
Monkey (8)
Rabbit (12)
Xenopus (4)
Zebrafish (8)
Application
IHC (25)
IHC-P (8)
WB (35)
ELISA (13)
IF (2)
IP (1)
Host
rabbit (39)
Isotype
IgG (19)
Clonality
polyclonal pc (39)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Unconjugated (17)
Epitope
aa329-358 (8)
N-Terminus (4)
aa201-250 (4)
aa23-72 (4)
aa1-330 (1)
Publications
No (39)
Showing 1-25 of 39 results

PTPN2 / TC-PTP Antibody (aa201-250) LS-C80715
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Xenopus, Chicken, Zebrafish, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg  $365.00
PTPN2 / TCPTP antibody PTPN2(protein tyrosine phosphatase, non-receptor type 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Transfected 293T cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PTPN2 / TCPTP antibody PTPN2(protein tyrosine phosphatase, non-receptor type 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Transfected 293T cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PTPN2 / TC-PTP Antibody (aa201-250, Biotin) LS-C447589
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $385.00
PTPN2 / TCPTP antibody PTPN2(protein tyrosine phosphatase, non-receptor type 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Transfected 293T cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PTPN2 / TCPTP antibody PTPN2(protein tyrosine phosphatase, non-receptor type 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Transfected 293T cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PTPN2 / TC-PTP Antibody (aa329-358) LS-C158768
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
PTPN2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human placenta tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
PTPN2 Antibody western blot of CEM cell line lysates (35 ug/lane). The PTPN2 antibody detected the PTPN2 protein (arrow).
PTPN2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human placenta tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
PTPN2 Antibody western blot of CEM cell line lysates (35 ug/lane). The PTPN2 antibody detected the PTPN2 protein (arrow).

PTPN2 / TC-PTP Antibody (N-Terminus) LS-C116296
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Rabbit, Mouse, Guinea pig, Rat, Horse, Human
WB
Unconjugated
50µg  $365.00
PTPN2 / TCPTP antibody Western blot of ACHN lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
PTPN2 / TCPTP antibody Western blot of ACHN lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PTPN2 / TC-PTP Antibody LS-C755253
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Human
ELISA IF IHC WB
Unconjugated
100µg  $355.00

PTPN2 / TC-PTP Antibody LS-C331703
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded mouse lung using PTPN2 antibody at dilution of 1:100 (200x lens).
Immunohistochemistry of paraffin-embedded rat kidney using PTPN2 antibody at dilution of 1:100 (200x lens).
Immunohistochemistry of paraffin-embedded mouse lung using PTPN2 antibody at dilution of 1:100 (200x lens).
Immunohistochemistry of paraffin-embedded rat kidney using PTPN2 antibody at dilution of 1:100 (200x lens).

PTPN2 / TC-PTP Antibody (aa1-330) LS-C407713
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Dog, Rat, Hamster, Human
IHC IHC-P WB
Unconjugated
100µg  $325.00
TCPTP antibody IHC-paraffin. IHC(P): Rat Kidney Tissue.
TCPTP antibody IHC-paraffin. IHC(P): Human Intestinal Cancer Tissue.
TCPTP antibody IHC-paraffin. IHC(P): Rat Kidney Tissue.
TCPTP antibody IHC-paraffin. IHC(P): Human Intestinal Cancer Tissue.

PTPN2 / TC-PTP Antibody (aa329-358) LS-C324417
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Human
ELISA IHC WB
Unconjugated
200µl  $530.00

PTPN2 / TC-PTP Antibody (aa329-358, Biotin) LS-C267554
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

PTPN2 / TC-PTP Antibody (aa329-358, FITC) LS-C267555
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

PTPN2 / TC-PTP Antibody (aa329-358, AP) LS-C267552
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

PTPN2 / TC-PTP Antibody (aa329-358, APC) LS-C267553
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

PTPN2 / TC-PTP Antibody (aa329-358, Azide-free, HRP) LS-C267556
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

PTPN2 / TC-PTP Antibody (aa329-358, PE) LS-C267558
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

PTPN2 / TC-PTP Antibody LS-C490178
Rabbit Polyclonal (IgG) to Human PTPN2 / TC-PTP
Rat, Human
IHC IHC-P WB
Unconjugated
100µg  $365.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

PTPN2 / TC-PTP Antibody LS-C488861
Rabbit Polyclonal to Mouse PTPN2 / TC-PTP
Mouse
ELISA IP WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

PTPN2 / TC-PTP Antibody LS-C663333
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.

PTPN2 / TC-PTP Antibody (HRP) LS-C712569
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $680.00; 10ml  $2,730.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.

PTPN2 / TC-PTP Antibody (Biotin) LS-C687936
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Human
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $265.00; 200µl  $315.00; 1ml  $575.00; 10ml  $2,310.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.

PTPN2 / TC-PTP Antibody (FITC) LS-C694845
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.

PTPN2 / TC-PTP Antibody (Cy3) LS-C703550
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Human
IHC WB
Cy3 Conjugated
20µl  $245.00; 100µl  $355.00; 200µl  $445.00; 1ml  $1,050.00; 10ml  $4,200.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.

PTPN2 / TC-PTP Antibody (APC, Cy7) LS-C735557
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Human
IHC WB
APC, Cy7 Conjugated
20µl  $285.00; 100µl  $455.00; 200µl  $635.00; 1ml  $1,575.00; 10ml  $6,300.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.

PTPN2 / TC-PTP Antibody (APC) LS-C718358
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $305.00; 200µl  $375.00; 1ml  $785.00; 10ml  $4,995.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.

PTPN2 / TC-PTP Antibody (PE) LS-C726631
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.
DAB staining on fromalin fixed paraffin- embedded kidney tissue
Western Blot; Sample: Recombinant PTPN2, Human.

PTPN2 / TC-PTP Antibody LS-C192885
Rabbit Polyclonal to Human PTPN2 / TC-PTP
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $385.00
Western blot of extracts of various cell lines, using PTPN2 antibody.
Western blot of extracts of various cell lines, using PTPN2 antibody.
Showing 1-25 of 39 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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