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PTP4A1 / PRL-1

protein tyrosine phosphatase type IVA, member 1

PTP4A1 / PRL-1 is a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X.

Gene Name: protein tyrosine phosphatase type IVA, member 1
Family/Subfamily: Protein Phosphatase , PTP4A
Synonyms: PTP4A1, HH72, PTPCAAX1, PTP(CAAXI), PRL-1, PRL1, PTP(CAAX1)
Target Sequences: NM_003463 NP_003454.1 Q93096

Publications (2)

1
PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells. Achiwa H, Lazo JS. Cancer research. 2007 67:643-50. [PubMed:17234774] Related Antibodies: LS-C55317.
2
New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53. Min SH, Kim DM, Heo YS, Kim YI, Kim HM, Kim J, Han YM, Kim IC, Yoo OJ. Oncogene. 2009 28:545-54. [PubMed:18997816] Related Antibodies: LS-C55317.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).