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PTN / Pleiotrophin

pleiotrophin

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Gene Name: pleiotrophin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: PTN, HARP, HBGF-8, HBNF, HB-GAM, HBBM, HBNF-1, Pleiotrophin, OSF-1, Osteoblast-specific factor 1, HBGF8, HBNF1, NEGF1
Target Sequences: NM_002825 NP_002816.1 P21246

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).