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PTHLH / PTHRP

parathyroid hormone-like hormone

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.

Gene Name: parathyroid hormone-like hormone
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: PTHLH, Osteostatin, PTHR, PTH-related protein, PTHRP, BDE2, HHM, PLP, PTH-rP
Target Sequences: NM_002820 NP_002811.1 P12272

Publications (6)

1
Bone adaptation in response to treadmill exercise in young and adult mice. Gardinier JD, Rostami N, Juliano L, Zhang C. Bone reports. 2018 January;8:29-37. [Full Text Article] [PubMed:29379848] [PMC:PMC5787623] Related Antibodies: LS-B6787.
2
The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting. Sawsan Elattar, Manali Dimri, Ande Satyanarayana. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 September;32:4727-4743. [Full Text Article] [PubMed:29570397] [PMC:PMC6266632]
3
Expression of Signaling Molecules Involved in Embryonic Development of the Insertion Site Is Inadequate for Reformation of the Native Enthesis: Evaluation in a Novel Murine ACL Reconstruction Model. Xiang-Hua Deng, Amir Lebaschi, Christopher L Camp, Camila B Carballo, Nathan W Coleman, Jianchun Zong, Brian M Grawe, Scott A Rodeo. The Journal of bone and joint surgery. American volume. 2018 August;100:e102. [Full Text Article] [PubMed:30063598] [PMC:PMC6661256] Related Antibodies: LS-B12325.
4
Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia. Brennan Olson , Mason A Norgard, Peter R Levasseur, Xinxia Zhu, Daniel L Marks. Journal of cachexia, sarcopenia and muscle. 2021 Oct;;12:1312-1332. [Full Text Article] [PubMed:34231343] [PMC:PMC8517353]
5
Parathyroid Hormone-Related Protein Inhibition Blocks Triple-Negative Breast Cancer Expansion in Bone Through Epithelial to Mesenchymal Transition Reversal. Jiarong Li, Anne Camirand, Mahvash Zakikhani, Karine Sellin, Yubo Guo, XiaoRui Luan, Catalin Mihalcioiu, Richard Kremer. JBMR plus. 2022 June;6:e10587. [Full Text Article] [PubMed:35720668] [PMC:PMC9189913] Related Antibodies: LS-C408680.
6
Whole-body and adipose tissue metabolic phenotype in cancer patients. Lindsey J Anderson, Jonathan Lee, Barbara Anderson, Benjamin Lee, Dorota Migula, Adam Sauer, Nicole Chong, Haiming Liu, Peter C Wu, Atreya Dash, Yi-Ping Li, Jose M Garcia. Journal of cachexia, sarcopenia and muscle. 2022 April;13:1124-1133. [Full Text Article] [PubMed:35088949] [PMC:PMC8977952]
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Products
ELISA Kits (28)
Competitive EIA (3)
Custom (2)
Sandwich (20)
Sandwich CLIA (3)
PTHLH / PTHRP (28)
Human (6)
Mouse (5)
Rat (7)
Bovine (1)
Chicken (2)
Dog (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (2)
12 x 8-Well Microstrips (1)
96-Well Microplate (3)
96-Well Strip Plate (23)
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Yes (2)
Cell Culture Supernatants (6)
Cell Lysates (6)
Plasma (21)
Serum (21)
Tissue Homogenates (10)
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$940
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$968
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
PTHLH / PTHRP ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PTHLH / PTHRP ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$929
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$889
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PTHLH / PTHRP ELISA Kit
Select
Competitive EIA
96-Well Microplate
Rabbit
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$581
PTHLH / PTHRP ELISA Kit
Select
Sandwich CLIA
Human
1.37 - 1000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$825
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$996
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
PTHLH / PTHRP ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
PTHLH / PTHRP ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
PTHLH / PTHRP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).