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Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
Gene Name: | parathyroid hormone 2 |
Synonyms: | PTH2, Parathyroid hormone 2, TIPF39, TIP39, Tuberoinfundibular 39 residues |
Target Sequences: | Q96A98 Q96A98 |
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