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PTGS2 / COX2 / COX-2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Gene Name:	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms:	PTGS2, COX-2, Cyclooxygenase-2, COX2, Cyclooxygenase 2b, HCox-2, GRIPGHS, PGH synthase 2, PGHS-2, PHS II, PHS-2, Prostaglandin H2 synthase 2, PGG/HS, Prostaglandin G/H synthase 2
Target Sequences:	NM_000963 NP_000954.1 P35354

Publications (7)

Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. Guan Z, Buckman SY, Miller BW, Springer LD, Morrison AR. The Journal of biological chemistry. 1998 273:28670-6. [PubMed:9786861] Related Antibodies: LS-B410.

Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. Tong M, Tai HH. Biochemical and biophysical research communications. 2000 276:77-81. [PubMed:11006085] Related Antibodies: LS-B410.

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK. Nature communications. 2018 April;9:1479. [Full Text Article] [PubMed:29662056] [PMC:PMC5902554]

Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity. Zhang MZ, Wang S, Wang Y, Zhang Y, Ming Hao C, Harris RC. Hypertension. 2018 November;72:1172-1179. [Full Text Article] [PubMed:30354807] [PMC:PMC6207229] Related Antibodies: LS-C210609.

N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease. Ju Youn Lee , Seung Hoon Han , Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H Schuchman, Hee Kyung Jin, Jae-Sung Bae. Nature communications. 2020 May;11:2358. [Full Text Article] [PubMed:32398649] [PMC:PMC7217877]

Fetal Sheep Mesenteric Resistance Arteries: Functional and Structural Maturation. Julia J Müller, Matthias Schwab, Charles R Rosenfeld, Iwa Antonow-Schlorke, Peter W Nathanielsz, Florian Rakers, Harald Schubert, Otto W Witte, Sven Rupprecht. Journal of vascular Research. 2017 August;54:259-271. [Full Text Article] [PubMed:28810262]

Extracellular vesicles in luminal fluid of the ovine uterus. Burns G, Brooks K, Wildung M, Navakanitworakul R, Christenson LK, Spencer TE. PloS one. 2014 9:e90913. [Full Text Article] [PubMed:24614226] [PMC:PMC3948691] Related Antibodies: LS-C150711.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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