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PTGS1 / COX-1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

Gene Name: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms: PTGS1, COX1, Cyclooxygenase-1, COX-1, PES-1, PGH synthase 1, Prostaglandin G/H synthase 1, PTGHS, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS 1, PHS1, Prostaglandin H2 synthase 1
Target Sequences: NM_000962 NP_000953.2 P23219

Publications (1)

1
Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries. Oghumu S, Casto BC, Ahn-Jarvis J, Weghorst LC, Maloney J, Geuy P, Horvath KZ, Bollinger CE, Warner BM, Summersgill KF, Weghorst CM, Knobloch TJ. Frontiers in immunology. 2017 October;8:1325. [Full Text Article] [PubMed:29109723] [PMC:PMC5660285]

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Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
PTGS1 / COX-1 (10)
No (10)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (6)
Mouse (1)
Rat (1)
293T Cells (2)
E. coli (3)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (1)
PTGS1 / COX-1 Protein - Recombinant Prostaglandin Endoperoxide Synthase 1 By SDS-PAGE
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E. coli
His, N-Terminal
30.4 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
PTGS1 / COX-1 Protein - 12.5% SDS-PAGE of human PTGS1 stained with Coomassie Blue
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Wheat Germ Extract
GST
95.1 kDa
2 µg/$439
PTGS1 / COX-1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PTGS1 / COX-1 Protein - Purified recombinant protein PTGS1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
65.9 kDa
20 µg/$1,107
PTGS1 / COX-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
68.66 kDa
20 µg/$150
PTGS1 / COX-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
61.8 kDa
20 µg/$215
PTGS1 / COX-1 Protein - Recombinant Prostaglandin Endoperoxide Synthase 1 By SDS-PAGE
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E. coli
His-T7
32.9 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
PTGS1 / COX-1 Protein - Recombinant Prostaglandin Endoperoxide Synthase 1 By SDS-PAGE
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E. coli
His
23.6 kDa
10 µg/$293; 50 µg/$515; 100 µg/$822; 200 µg/$1,024; 1 mg/$2,177; 500 µg/$1,698; 5 mg/$3,599; 2 mg/$2,368
PTGS1 / COX-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
68.66 kDa
100 µg/$494
PTGS1 / COX-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
61.8 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).