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PTGER4 / EP4

prostaglandin E receptor 4 (subtype EP4)

PTGER4 / EP4 is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Gene Name: prostaglandin E receptor 4 (subtype EP4)
Family/Subfamily: GPCR , Prostanoid
Synonyms: PTGER4, EP4, EP4 prostaglandin receptor, EP4R, PGE receptor EP4 subtype, Prostanoid EP4 receptor, Prostaglandin E receptor 4, PGE receptor, EP4 subtype, PGE2 receptor EP4 subtype
Target Sequences: NM_000958 NP_000949.1 P35408

Publications (3)

1
EP4 and Class III ß-Tubulin Expression in Uterine Smooth Muscle Tumors: Implications for Prognosis and Treatment. Reader J, Harper AK, Legesse T, Staats PN, Goloubeva O, Rao GG, Fulton A, Roque DM. Cancers. 2019 October;11:E1590. [Full Text Article] [PubMed:31635323] [PMC:PMC6826612] Related Antibodies: LS-A3898.
2
Prostaglandin E Receptor EP4 expression, survival and pattern of recurrence in locally advanced NSCLC. Neha Bhooshan, Paul N Staats, Amy M Fulton, Josephine L Feliciano, Martin J Edelman. Lung cancer (Amsterdam, Netherlands). 2016 November;101:88-91. [Full Text Article] [PubMed:27794413] [PMC:PMC7428069] Related Antibodies: LS-A3898.
3
Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model. Terada N, Shimizu Y, Kamba T, Inoue T, Maeno A, Kobayashi T, Nakamura E, Kamoto T, Kanaji T, Maruyama T, Mikami Y, Toda Y, Matsuoka T, Okuno Y, Tsujimoto G, Narumiya S, Ogawa O. Cancer research. 2010 Feb;70:1606-15. [Full Text Article] [PubMed:20145136] Related Antibodies: LS-A3898.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).