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PTGER3 / EP3
prostaglandin E receptor 3 (subtype EP3)
Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems.
| Gene Name: | prostaglandin E receptor 3 (subtype EP3) |
| Family/Subfamily: | GPCR , Prostanoid |
| Synonyms: | PTGER3, Ep3 prostanoid receptor, Ep3 receptor, EP3-I, EP3e, EP3-II, EP3-III, EP3-IV, PGE receptor, EP3 subtype, Prostaglandin receptor (PGE-2), Prostaglandin ep3 receptor, Prostanoid EP3 receptor, PGE receptor EP3 subtype, Pge2 receptor ep3, PGE2 receptor EP3 subtype, Prostaglandin E receptor 3, Prostaglandin e2 receptor ep3, EP3, Ep3 subtype pge2 receptor, PGE2-R, Prostaglandin E receptor EP3 |
| Target Sequences: | NM_000957 NP_000948.2 P43115 |
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