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PTENP1
phosphatase and tensin homolog pseudogene 1 (functional)
The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity.
| Gene Name: | phosphatase and tensin homolog pseudogene 1 (functional) |
| Family/Subfamily: | Protein Phosphatase , PTEN |
| Synonyms: | PTENP1, PsiPTEN, MMAC1, PTEN-rs, PTEN2 |
| Target Sequences: | AF019083 O43460 |
![PTENP1 Antibody - Western blot using the affinity purified anti-PTEN-P1 antibody shows detection of endogenous PTEN-P1 in whole cell lysates from human derived cell lines HeLa (lane 4), HEK293 (lane 5) and MCF7 (lane 6). The band at ~55 kDa (arrowhead) corresponds to PTEN-P1. Lanes 1-3 were show the results of staining after the antibody was first pre-incubated with the immunizing peptide. The identity of lower molecular weight bands in lane 4 is unknown. Briefly, each lane contains approximately 35 µg of lysate. Primary antibody was used at a 1:500 dilution in 5% BLOTTO in PBS reacted overnight at 4°C. The membrane was washed and reacted with a 1:10,000 dilution of conjugated Gt-a-Rabbit IgG [H&L] MX for 45 min at room temperature (800 nm channel, green). Molecular weight estimation was made by comparison to prestained MW markers in lane M (700 nm channel, red). Fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. Other detection systems will yield similar results.](https://lsbio-7d62.kxcdn.com/image2/ptenp1-antibody-n-terminus-ls-c745317/445761_5255223.jpg)
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