PTEN

phosphatase and tensin homolog

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.

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Products

Proteins (9)

Type

Over-Expression Lysate (3)

Recombinant (6)

Target

PTEN (9)

Publications

No (9)

Tag

6His, N-terminus (1)

8His, N-terminus (1)

His (2)

His, N-Terminal (1)

His, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (3)

Sf9 Cells (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human PTEN Protein (Recombinant 6His, N-terminus) (aa2-403) - LS-G15717

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

48.6 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human PTEN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66775

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47 kDa

Price:

20 µg/$1,107

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Human PTEN Protein (Over-Expression Lysate 8His, N-terminus) (Thr2-Val403) - LS-G26716

Source:

HEK 293 Cells

Tag:

8His, N-terminus

Molecular Weight:

48.6 kDa

Price:

100 µg/$298

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Human PTEN Protein (Recombinant His, N-terminus) - LS-G145972

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

46.8 kDa

Price:

20 µg/$270; 100 µg/$390

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Human PTEN Protein (Recombinant His) (aa288-403) - LS-G141037

Source:

E. coli

Sequence Length:

115 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

12.76 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human PTEN Protein (Recombinant His, N-Terminal) - LS-G142328

Source:

Sf9 Cells

Tag:

His, N-Terminal

Molecular Weight:

47 kDa

Price:

20 µg/$677

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PTEN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123273

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47 kDa

Price:

100 µg/$494

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Human PTEN Protein (Recombinant His) - LS-G583

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$739; 10 µg/$292; 50 µg/$523; 250 µg/$1,285; 500 µg/$1,917

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Human PTEN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78478

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47 kDa

Price:

20 µg/$150

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