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PTCH1 / Patched 1

patched 1

PTCH1 / Patched 1 is a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Gene Name: patched 1
Synonyms: PTCH1, NBCCS, Patched 1, Patched homolog 1, Protein patched homolog 1, PTC1, PTCH, PTCH protein +12b, PTCH protein -10, PTCH protein -3,4,5, Patched, Patched protein homolog 1, BCNS, HPE7, Patched homolog, PTC, PTCH protein +4, PTCH11
Target Sequences: NM_000264 NP_000255.2 Q13635

Publications (3)

1
Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. Klein C, Zwick A, Kissel S, Forster CU, Pfeifer D, Follo M, Illert AL, Decker S, Benkler T, Pahl H, Oostendorp RA, Aumann K, Duyster J, Dierks C. The Journal of experimental medicine. 2016 213:273-90. (WB, ELISA; Human) [Full Text Article] [PubMed:26834157] [PMC:PMC4749921] Related Antibodies: LS-B3939.
2
Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human. Erik Kolbe, Susanne Aleithe, Christiane Rennert, Luise Spormann, Fritzi Ott, David Meierhofer, Robert Gajowski, Claus Stöpel, Stefan Hoehme, Michael Kücken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja. Cell reports. 2019 December;29:4553-4567.e7. [Full Text Article] [PubMed:31875560]
3
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Yang Gu , Yanying Wang , Luyun He , Jiahang Zhang , Xiaoxiao Zhu , Nian Liu, Jianyi Wang, Tiankun Lu, Lei He, Yong Tian, Zusen Fan. Molecular cancer. 2021 October;20:132. [Full Text Article] [PubMed:34649567] [PMC:PMC8515748] Related Antibodies: LS-C114391.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
PTCH1 / Patched 1 (8)
No (8)
DDK,C-terminus (1)
GST (1)
GST, N-terminus (2)
His-T7 (2)
Myc-DDK (Flag) (2)
Human (6)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Sf9 Cells (1)
Wheat Germ Extract (3)
Purified (1)
PTCH1 / Patched 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Wheat Germ Extract
GST, N-terminus
25 µg/$670; 10 µg/$479
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293T Cells
Myc-DDK (Flag)
160.4 kDa
20 µg/$215
PTCH1 / Patched 1 Protein - Recombinant Patched 1 By SDS-PAGE
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E. coli
His-T7
27.3 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
PTCH1 / Patched 1 Protein
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E. coli
His-T7
27.4 kDa
10 µg/$274; 50 µg/$397; 100 µg/$635; 200 µg/$792; 1 mg/$1,864; 500 µg/$1,419; 5 mg/$2,826; 2 mg/$2,047
PTCH1 / Patched 1 Protein - 12.5% SDS-PAGE of human PTCH stained with Coomassie Blue
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Wheat Germ Extract
GST
47.2 kDa
2 µg/$439
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Sf9 Cells
DDK,C-terminus
30.4 kDa
20 µg/$677
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HEK 293 Cells
Myc-DDK (Flag)
160.4 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).